HEREDITARY POLYDACTYLISM

The Phenotypic Modification of Hereditary Polydactylism of Fowl by Selection and by Insulin.

T IS known from earlier investigations that hereditary polydactylism of I fowl has a variable phenotype. The present report deals with two separate attempts to modify experimentally the expression of this mutation. In the first part we shall relate the results of matings which were made in order to test the effect of seledtion on several distinct phenotypes of polydactylism. In the second part ...

Inheritance of Polydactylism in the Fowl.

Changes of tumor susceptibility arising concomitantly with a reversal of polydactylism in mice.

A change in susceptibility to tumor transplantation with the use of two sarcomas is reported in this paper to have arisen concomitantly with the sudden reversal in the penetrance of polydactylism in mouse//46801 of the Strong Polydactylous strain. Mice of the subline derived from #46801 grew the tumors in only 68 and 78 per cent of the cases, whereas the same subline without the polydactylism r...

Unilateral Polydactylism in a German Holstein-Friesian Calf - A case report

This case report describes the diagnosis and surgical treatment of unilateral polydactylism of unknown origin in a calf. A six-week-old female German Holstein-Friesian calf was referred to the clinic with a hyperflexion of the fetlock and carpal joints of the right forelimb, associated with two surplus digits in the same leg, which was confirmed by radiographic examination. Surgery consisted of...

Expandable DNA Repeat and Human Hereditary Disorders

Background & Aims: Nearly 30 hereditary disorders in humans result from an increase in the number of copies of simple repeats in genomic DNA, including fragile X syndrome, myotonic dystrophy, Huntington’s disease, and Friedreich’s ataxia. One the most frequently occurring types of mutation is trinucleotide repeat expansion. The present study was conducted with the aim of investigating the cause...